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Multiple studies have reported that Epithalon administration can extend both mean and maximum lifespan by 10-25% or more compared to control animals - effects approaching those seen with caloric restriction

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For example, PRMT1-mediated STAT6 methylation, induced by hypoxia-inducible factor (HIF)-1, promoted M2 macrophage polarization, contributing to fibrotic signaling in lung epithelial cells [91]