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Reactive astrocytes protect the CNS by releasing neurotrophic factors (for example, NGF, TGF-, LIF and BDNF) and cytokines that promote neuronal survival and create an anti-inflammatory environment 46,47

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In recent work, Lopes and colleagues demonstrated that caffeine increased the energy charge and redox state of cortical synaptosomes, suggesting that this effect led to an increase in the glycolytic rate, thereby enhancing astrocyte-synapse lactate transport

[80] published a study about cardiac abnormalities (cardiac hypertrophy and dysfunction) in childhood with obesity using a model of high-fat dietinduced obesity young mice

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