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In MDA-MB-231 cells, CuPDTC induces calpain-dependent PARP1 cleavage and apoptosis, and this process is reversed by calpastatin (a calpain inhibitor) (Milacic et al., 2008)

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Tan L., Zhong M.M., Liu Q., Chen Y., Zhao Y.Q., Zhao J., Dusenge M.A., Feng Y., Ye Q., Hu J., et al

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Front Med 2018

However, spread to bones, distant lymph nodes, lungs, and liver can be seen in stage IVB [81]

First, this process concerns the protection of the kidneys, both in a diseased state, when nephroprotective actions prevent the worsening of symptoms, and when they are healthy, through actions preventing the development of diseases and disorders