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In SCI patients and rats, iron deposits in the motor cortex are significantly increased, triggering the accumulation of ROS, and eventually leading to ferroptosis in motor neurons

Mah PM, Webster J

10.1093/eurheartj/ehy339 27

Neuroendocrinology 78 , 210216 (2003)

In a study of hepatocellular carcinoma, it was found that overexpression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) can inhibit ferroptosis while promoting pyroptosis, whereas HMGCR knockdown produced the opposite results [299]