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This dysbiosis is driven by multiple factors, including intestinal urea accumulation, impaired ammonia metabolism secondary to renal dysfunction, dietary modifications, and medical interventions ( Figure 2 ) [35, 111]

Role of horizontal gene transfer in the development of multidrug resistance in Haemophilus influenzae

Cerebrovascular diseases Cerebrovascular diseases (including stroke and sub-acute ischemic cerebrovascular disease) are the main cause of cognitive impairments in older people

In mitochondria, DHODH can reduce CoQ to ubiquinol (CoQH2), reducing oxygen free radicals, inhibiting the generation of phospholipid hydroperoxide (PLOOH), and inhibiting phospholipid peroxidation, thereby inhibiting ferroptosis

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This distinction matters enormously for long-term use, where indiscriminate inflammation suppression can compromise immune function and healing capacity