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Multi Omics Analysis Reveals Chronic Cisplatin Exposure Is Associated with Metabolic Rewiring Toward Glutathione Metabolism to Support Redox Adaptation in High Grade Serous Ovarian Cancer Role of Glutathione in Cancer: From Mechanisms to Therapies Glutathione responsive nanomedicine leverages tumor redox imbalance for targeted cancer theranostics Discover Oncology Springer Nature Link Facile Hydrophobication of Glutathione Protected Gold Nanoclusters and Encapsulation into Poly(lactide co glycolide) Nanocarriers Scientific Reports Glutathione Dependent Pathways in Cancer Cells The crosstalk between glutathione metabolism and non coding RNAs in cancer progression and treatment resistance ScienceDirect

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Neuroendocrinology Letters, 24 (3/4), 233-240

However, direct evidence of such genetic differences as time-dependent adaptation (evolutionary change in the context of climate change) remains rare

The DONEPEZOX trial, as a proof-of-concept, randomized, triple-blind, and multicenter study, will be the first clinical trial to evaluate the efficacy and safety of donepezil in oxaliplatin for gastrointestinal cancer-induced severe peripheral neuropathy (OIPN), with the response rate in the donepezil group (neuropathy grade reduction according to the QLQ-CIPN20 sensory score) as the primary endpoint [168]