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One vial holds both compounds at a fixed ratio (10/3 or 5/5)

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doi: 10.3122/jabfm.2009.05.090044

(full study link in comments below) Also, this paragraph from #Katzungs_basic_and_clinical_pharmacology, 16th edition (2023), page 798: (the paragraph's picture is in comments) [[[[ Metformin interferes with the calcium-dependent absorption of vitamin B12-intrinsic factor complex in the terminal ileum, and vitamin B12 deficiency can occur after many years of metformin use

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The space between epithelial cells turns out to be just as scientifically significant as the cells themselves