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About 1 in 10 people aged 55 years and over are affected by PN, and the most common cause is diabetes

It is also possible that this finding is associated with the underlying pathophysiology that produces FRAs

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A number of causes other than xenobiotic exposure, such as chronic hepatic injury, diet, metabolic and hormonal status, debilitation of animals, and fasting before necropsy, should be taken into consideration in reviewing these changes (Vollmar et al

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