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However, accumulating evidence also highlights a potential nephrotoxic liability associated with andrographolide, particularly under conditions of high-dose exposure or unfavorable formulations

& Gotteland, M

Importantly, no liver decompensation or mortality was observed

Collectively, the evidence supports suppressing apoE in APOE- 4 carriers as a therapeutic strategy, but further experiments are required to verify efficacy and off-target effects of ASOs and immunotherapies targeting apoE

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However, in reality, theres a lot of difference between the two