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Studied for effects on glucose tolerance and insulin response in preclinical models of metabolic syndrome

CB1 antagonists block the interaction of endocannabinoids, such as the endogenous CB1 agonist anandamide, with CB1 receptors by binding to the CB1 receptor

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NKp44 + NK cell-mediated destruction of the intestinal epithelium in UC, and HLA-DP401 can engage NKp44 and activate NKp44 + NK cells, mediating damage to intestinal epithelial cells (IECs) in an HLA-DP haplotype-dependent manner

For shRNA experiments, sh SLC7A11 was induced with doxycycline chow (600 mg kg 1 , Specialty Feeds, Australia) and water (2 mg ml 1 , Sigma-Aldrich) available ad libitum

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