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108 In murine B78 melanoma models, this combinatorial in situ cancer vaccine triggered robust activation of B cells, leading to class-switched IgG responses (IgG1, IgG2b, IgG2c, and IgG3) that specifically recognized tumor antigens shared between B78 and B16 cells

To investigate the impact of shifting from cystine-driven to GSH-driven cysteine supply in cancer cells in an unbiased manner, we performed a multifunctional approach to pharmacological screening (MAPS) with a library of 240 metabolic inhibitors (Fig

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Wu X, Chen PS, Dallas S et al (2008) Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

This is particularly important since most of the antipsychotic medications used in ASD patients carry a substantial metabolic burden with well-known weight gain effects [127]

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