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2 Activated JAK induces the phosphorylation of STAT3, which translocates to the nucleus, where it promotes the expression of cell proliferation-related genes

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doi: 10.1513/AnnalsATS.201510-712PS

doi: 10.1007/s10096-016-2881-8 24 TilgHAdolphTEGernerRRMoschenAR

Finally, delineating tissue-preferential effects is essential to determine whether improvements in IR arise primarily from reduced hepatic lipid content or also involve amelioration of pancreatic steatosis and skeletal muscle lipid metabolism