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If we go back to first principles and foundational biochemistry, we definitely want to support glutathione production, via its precursor amino acids: cysteine, glycine, and glutamate, and the biochemical pathways and cofactors involved in its production (e.g., methylation cycle, B vitamins especially B2, B3, B6, B9,and B12)

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The addition of exogenous ROS results in resensitization of cells with high VRK2 expression to GSH inhibition, which is consistent with the fact that PC cells with low expression of VRK2 are susceptible to GSH inhibition attributes to its high basal ROS level, suggesting that cells in a state of oxidative stress have enhanced dependence on the GSH system

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The differential equation for the concentration of cytosolic cysteine (Cys) is straightforward: The first term on the right is the production of cysteine from cystathionine (Cysta) by CGTL and the second term is the import of cysteine into the cell, which depends on the concentration of cysteine in the blood ([bCys])

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