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When ERAD capacity is overwhelmed or dysfunctional, unresolved ER stress ensues, driving metabolic dysregulation and disease progression (Fig

Kalynchuk, [email protected] This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

in PNAS in November 2020

By supporting healthy antioxidant activity and cellular function, glutathione helps maintain the body's natural defense systems and contributes to overall wellness and healthy aging

Disclosure of interest: Lupei Cai: nothing to disclose

The C-terminal domain contributes, together with the N-terminal domain, to shaping the co-substrate binding site, which is termed H-site, from the hydrophobic nature of co-substrates