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Evaluation of nerve regeneration Nerve conduction, histopathologic, and immunohistochemical studies of the sciatic nerves of the three groups were performed 15 weeks after the injury

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Consequently, its clinical relevance is profound: it provides a mechanistic explanation for the heterogeneous treatment response observed in practice and introduces a measurable pathological processdysregulated lactate metabolismthat can be therapeutically targeted [93]

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This knockdown also induces lactylation at the K73 site in ADP-ribosylation factor 1 (ARF1), which affects vesicle assembly and induces mitochondrial loading abnormalities, thereby blocking the release of mitochondria from astrocytes, ultimately exacerbating the extent of brain infarction in mice

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