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Front Immunol 15:1463767 Park B et al (2019) Polydatin inhibits NLRP3 inflammasome in dry eye disease by attenuating oxidative stress and inhibiting the NF-B pathway

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Malonyl-CoA is the product of the carboxylation of acetyl-CoA by the enzyme acetyl-CoA carboxylase (ACC), the first step in de novo fatty acid synthesis (Ameer et al., 2014), and it acts as a potent inhibitor of mammalian -oxidation in the liver (McGarry and Brown, 1997)