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Acetaldehyde and ROS generated during alcohol metabolism can directly stimulate KCs and HSCs, promoting the transcription and secretion of TNF- [124, 125]

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thus, we used as many intact individuals as possible as parents

To further increase the ERG yield, we focused next on reinforcing the sulfur metabolic flux toward ERG biosynthesis, because this pathway was indicated to be the rate-limiting pathway in our previous study 26