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One may speculate that RGC loss in these NTG models are due to degeneration in the brain, leading to loss of neural connections between the visual center in the brain and the retina

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Similar to SGLT2i, some glucagon-like peptide 1 receptor agonists (GLP1RA) have demonstrated a reduction of cardiovascular endpoints in clinical trials, including MACE or CV death alone, thus resulting in a similar guideline recommendation as described before for SGLT2i [147148]

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Analysis of pro-apoptotic protein trafficking to and from mitochondria

Int J Reprod Med Aprioku JS, Ugwu TC (2016) Tobacco smoke exposure induces irreversible alteration of testicular function in prepubertal rats