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Acknowledgements This work was supported, in part, by the Shenzhen Fundamental Research Program (JCYJ20220818100617036), the Shenzhen Medical Research Funds (B2402033), the National Natural Science Foundation of China (82261160395, 82430078, 82230081, 82250710175, and 82004395), the Guangdong Provincial Science and Technology Innovation Council Grant (2017B030301018), the Shenzhen Key Laboratory of Cell Microenvironment Grant (ZDSYS20140509142721429), and the Guangdong Provincial Bureau of Traditional Chinese Medicine Project (20212203)

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