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As (III) exerts dual-barrier disruption through CAPN-1 activation: rapid calcium influx triggers VE-cadherin degradation at adherens junctions, while chronic exposure downregulates ACE2/MasR axis, impairing the protective renin-angiotensin system (117, 118)

Third, the single-center cohort limits generalizability, and selection bias may exist due to the exclusion of patients lost to follow-up

Statistical significance was established using one-way analysis of variance (ANOVA) and Tukeys post-hoc test for multiple comparisons in SPSS (version 20.0) software (IBM SPSS Statistic 20.0, Armonk, NY, USA)

doi: 10.1016/j.enceco.2024.07.002 59 DingJ.LiuY.GaoY.ZhangC.WangY.XuB.et al

Gong Y, Qiu J, Jiang T, Li Z, Zhang W, Zheng X, He Z, Chen W, Wang Z, Feng X, Wang M, Hong Z (2023) Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K/AKT/NF-B pathway and regulating NLRP3 inflammasome-mediated pyroptosis

Over-the-counter pain medicines: acetaminophen APAP, the active ingredient found in Tylenol, Panamax, Excedrin, and Panadol, is generally prescribed and available as an over-the-counter medicine to treat pain, fever, and inflammation by reducing the production of prostaglandins