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one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulates intracellular NAD+ levels to provide muscular therapy

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Meanwhile, it is capable of awakening dormant senescent muscle stem cells (muSCs) and repairing their impaired physiological functions, which prominently upgrades the inherent regenerative potential of naturally aged skeletal muscle tissue

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As of 2026, the body of preclinical research for both compounds has grown significantly, providing a clearer picture of their distinct mechanisms