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Particularly under hypoxic conditions or mitochondrial dysfunction, the level of -KGDH-catalyzed -KG production of succinate is reduced in cancer cells (standard TCA cycle reaction)

Subsequent studies demonstrated the appearance of this truncated form in cells and animals exposed to pro-inflammatory conditions [36] or to hypoxia [37]

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The strong relationship between antioxidants and neurodegenerative diseases must therefore be given close attention

Peh noted that after Heliocare took off in the APAC region, the company began seeing the problem of divergence, which in turns affected price control

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