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Due to the relatively short sequence length and defined helical conformation, the minimal fragment ACE2 (2442) becomes a perfect choice of peptide sequence for developing inhibitors to disturb the hACE2/spike PPI and stop SARS-CoV-2 invading normal cells based on peptide stapling techniques

Indeed, local injection of oxalate into the footpad of mice induces spontaneous nocifensive behavior as well as mechanical allodynia, albeit the dose required to observe this effect is considerably higher than the dose of oxaliplatin required to induce neuropathic pain (Deuis et al., 2013)

However, even though hypozincemia seems to be a common feature of obesity, it is not a direct cause of the disease (108)

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