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Loss of farnesoid X receptor (FXR) exacerbated the ferroptosis signaling pathway by enhancing iron accumulation, increasing lipid peroxidation, decreasing GSH levels and reducing GPX4 expression in cisplatin-treated mice and HK-2 cells [175]

However, two studies showed some benefits of chemotherapy

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Populations of particular concern based on mechanism and the absence of human data include: individuals with active or suspected malignancy (pro-angiogenic preclinical profile)

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