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The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier

doi:10.1001/jamanetworkopen.2020.34018 Springer Science+Business Media

The aggresome pathway is particularly important in neurons, which are highly susceptible to the accumulation of misfolded proteins due to their long lifespan and complex structure

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After precipitation, samples were digested overnight using LysC and trypsin (1:100 enzyme/protein ratio) at 37 C using a ThermoMixer set to 1,200 rpm

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