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I think it's really it really started started to change where I heard, I heard people talking about it in the early 2000s

[2] [4] Typical intracellular labile iron concentrations in bacteria are 1020 micromolar, [5] though they can be 10-fold higher in anaerobic environment, [6] where free radicals and reactive oxygen species are scarcer

The peptide interacts with the nitric oxide (NO) system, modulating vascular tone and cell signaling at the microenvironmental level to support the transition from the inflammatory phase to the proliferative phase of healing

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The apparent lack of a direct effect was noted due to the in vitro environment not mimicking the inherent environment of a tendon in vivo

Biochemistry 2009