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Peptides are short chains of amino acids that serve as cellular messengers, regulating numerous processes such as: As the body ages, endogenous peptide levels decline, contributing to reduced healing, metabolic slowdown, and diminished resilience (Hobson et al., 2021)

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For PHH, PRH, and HepG2 cells with hamster S9-mix, NDELA was consistently in the lower sensitivity part of the compound ranking, whereas no clear trend was present for NMIPA or NDMA

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However, this model appears closer to the physiological reality of the human eye than phototoxicity studies performed on non-differentiated ARPE-19 cells for which the phenotype and gene expression greatly differ from the ones of native RPE cells 42