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doi: 10.3747/co.25.4096 52 CassidyRJZhangXPatelPRSheltonJWEscottCESicaGLet al

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2018 Moreover, 8-OHD markedly quenched reactive oxygen species (ROS) and activated NF-E2-related factor 2 (Nrf2) so as to upregulate expression of Phase II enzymes, including heme oxygenase (HO)-1, NADH quinone dehydrogenase 1 (NQO1), and the modifier subunit of glutamate cysteine ligase (GCLM)

shRNA-mediated PPAR knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth

Furthermore, increased OS/NS levels were suggested as one of the major factors contributing to the physiological and pathological alteration of the UPS