Neonatal growth parameters, such as head circumference, femur length, and estimated fetal weight were inversely associated with a state of iodine excess (86)
Mast Cell Hyper-Reactivity (MCAS): As a potent antioxidant, glutathione neutralizes the reactive oxygen species that directly trigger mast cell degranulation, helping to stabilize these immune cells and reduce the systemic release of inflammatory mediators
While our study contributes to our understanding of the metabolic consequences of DON exposure, its essential to consider these findings within the broader context of various factors, including genetics, environmental triggers, and lifestyle factors, which collectively contribute to the development of autoimmune diseases
Validating urine-based biomarkers (e.g., glomerular cell-derived exosomal ferroptosis regulators, and 4-HNE metabolites) or circulating signatures that correlate with IgA nephropathy disease activity, pathological severity, or response to interventions is urgently needed to guide clinical trial design and patient stratification
Briefly, the authors developed a stable clone by transfecting MCF7 cells with the cDNA of human cytosolic GPx1
Ding SB, Chu XL, Jin YX, Jiang JJ, Zhao X, Yu M (2023) Epigallocatechin gallate alleviates high-fat diet-induced hepatic lipotoxicity by targeting mitochondrial ROS-mediated ferroptosis