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However, a central hypothesis presented in this study is that the AT4 receptor system coincides with the HGF/c-Met receptor system

NRF2 inhibitors such as brusatol have been explored for cancer treatment, and NRF2 activators show promise in preventing cancer or protecting cells from acute oxidative damages such as radiation during cancer treatment [179]

This connects serine/one-carbon metabolism to antioxidant defense explaining why serine depletion reduces GSH levels and sensitizes tumor cells to oxidative stress

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Prajapati, and A

These two enzymes are involved in the biosynthesis of allopregnanolone (ALLO) and tetrahydrodeoxycorticosterone (THDOC)