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Cultured cells have limited lifespans, restricting long-term investigations into processes like amyloid plaque accumulation, tau tangle formation, and progressive neuronal degeneration (Rodriguez-Jimenez et al., 2023)

Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo

For instance, mitochondrial ROS activate the NLRP3 inflammasome to drive pyroptosis, while TGF- and ROS form a self-amplifying loop that accelerates fibrotic progression

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In a follow up study, Cameron and Pauling reported that 22% of vitamin C-treated cancer patients survived for more than one year compared to only 0.4% of control patients