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Some of the more clinically important types of atherosclerosis are 22-24 : Coronary artery disease , which affects the arteries of the heart Peripheral artery disease , which usually affects the arteries in the legs, but may involve arteries in the arms or pelvis Cerebrovascular disease , which involves the arteries that supply blood to the brain Aortic atherosclerosis , affecting the large artery (aorta) leading away from the heart Renal artery stenosis , which involves narrowing of the arteries that bring blood to the kidneys Mesenteric artery ischemia , which is a lack of blood flow to the intestines due to atherosclerosis Coronary artery disease is the most common type of heart disease, affecting over 20 million American adults, and is the leading cause of death in the United States