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The porcine pi-class enzyme pGTSP1-1 was the first GST to have its structure determined, and it is representative of other members of the cytosolic GST superfamily, which contain a thioredoxin-like N -terminal domain as well as a C -terminal domain consisting of alpha helices

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While both drugs act on the JAK/STAT signaling pathway, ritlecitinib results in inhibition of a narrower cytokine spectrum due to its selectivity for JAK3, whereas baricitinib inhibits both JAK1 and JAK2

doi: 10.1016/j.mrfmmm.2011.07.004

[DOI] [PubMed] [Google Scholar] 30.Ko T.P., Safo M.K., Musayev F.N., Di Salvo M.L., Wang C., Wu S.H., Abraham D.J