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Both agents are unlicensed in the UK for the indications most commonly sought, and combining them outside a supervised clinical trial is not recommended

Its isoform is mainly expressed in the brain and it is necessary for the normal lysosomal function of astrocytes

Chen found in human melanoma cells that silencing iPLA2 would enhance the sensitivity to p53-mediated ferroptosis without significant effects on cells that usually express iPLA2, suggesting that iPLA2 can inhibit p53-mediated ferroptosis, and p53-driven ferroptosis is independent of GPX4 [41]

It is estimated that over 5 million women in the United States suffer from PCOS, which leads to roughly $4 billion in healthcare costs every year (Sacca et al., 2024)