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Statistical analyses were performed using SPSS version 21 (SPSS Inc., Chicago, IL, USA)

doi: 10.1016/j.neulet.2009.11.065 70 JiangQ

264,265 Chronic hyperglycemia elevates ROS production through multiple pathways, including enhanced glucose oxidation, activation of NADPH oxidases, and dysfunction of the mitochondrial electron transport chain

Gong L, Yu L, Gong X, et al

Chapter fifteen

When NNMT is inhibited: NAD+ levels rise Mitochondria become more efficient Cells burn more energy, even at rest This effect helps the body shift into a more metabolically active state, making it easier to reduce fat and preserve muscle during weight loss