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Acknowledgements We would like to thank Editage (www.editage.cn) for English language editing

10.1213/ane.0000000000005146 15 LiN.WangT.WangN.FanM

[PubMed] [Frontiers] [PubMed] Setin-Suero E, Surez-Pinilla M, Surez-Pinilla P, Crespo-Facorro B, Ayesa-Arriola R

How B12 Injections Are Administered B12 Injections are typically administered either intramuscularly, where the vitamin is delivered directly into the muscle for rapid absorption, or subcutaneously, where it is placed under the skin for slower release

This potential link between impaired mitochondrial bioenergetics and ferroptotic vulnerability may not be apparent in short-term in vitro experiments, which are typically conducted in nutrient-rich media that support metabolic flexibility and compensate for transient energy deficits, explaining why iron chelators only suppress ferroptosis in this context