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FSP1 is one of the key regulatory molecules involved in ferroptosis, which regulated by upstream factors, including transcription factors and noncoding RNAs (ncRNAs), and is subject to epigenetic modifications, all of which influence the progression of ferroptosis-related diseases [30, 54]

All animal procedures were conducted in accordance with protocols approved by the Animal Ethics Committee of Soochow University

Chronic toxicity studies of R

Statistical analyses GraphPad Prism 8 was used for all statistical analyses

Normal range of GLDH activity is reported to be 7-11 U/L in men and 5-6.4 U/L in women

Step 3: Focus on elbows, knees, and neck