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D.MiwaJ.PantojaR.et al

Some of those are providing energy substrate, serving as a precursor to amino acid synthesis, the nitrogen donor in the formation of nucleic acids, aiding in the synthesis of intracellular proteins, and acting as an essential contribution to the acid-base balance [24]

On the other side, for ferroptosis-defending mechanisms that plays a suppressive role, mainly comprise four cellular antioxidant systems: the GPX4-GSH system, the FSP1-CoQH 2 system, the DHODH-CoQH 2 system, and the GCH1-BH 4 system [22]

In both PC-3 M-MM2 cells and PCa mouse models, the use of PI3 kinase inhibitors reduces AKT phosphorylation and miR-21 levels, indicating that miR-21 expression is dependent on the PI3K/AKT pathway [123]

Induction was less evident following ozone exposure (Figure 4)

The Pentose Phosphate Pathway (PPP) is a fundamental metabolic route that plays a critical role in maintaining cellular health and function