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Measurable NNMT suppression defined as 50% or greater reduction in serum N-methylnicotinamide (MNA) levels occurs within 710 days of daily subcutaneous dosing at 50mg/kg in murine models

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Clinical trials examining both symptom scores and objective measures of esophageal healing would evaluate this potential indication

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Most of us can get a sufficient amount of vitamin B12 purely through diet, but there are some cases where dietary restrictions make consuming the vitamin through food incredibly difficult, or where the body is not able to absorb the amount of vitamin B12 that it requires