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Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial

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MPL is formulated in a variety of adjuvant platforms, including AS01 (MPL and QS-21 in phosphatidylcholine liposomes), AS02 (MPL and saponin QS-21 in an oil-in-water emulsion containing squalene and -tocopherol) and AS04 (MPL adsorbed to aluminum oxyhydroxide)

Despite promising regenerative outcomes in animal modelssuch as achieving NP cell survival rates reaching 85%, a 3.3-fold increase in COL2 synthesis, and 87% recovery of disc height through spatiotemporally controlled release, ROS scavenging, and immune modulationsignificant challenges remain for clinical translation