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Activation of SIRT1 improves insulin sensitivity and regulates blood glucose level: SIRT1 can directly deacetylate and activate peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), thereby promoting mitochondrial biogenesis and enhancing cellular energy efficiency, which in turn strengthens tissue responsiveness to insulin [107]

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doi: 10.4172/2153-0645.1000141 149 KozlovE

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Anti-amnesic effects of withaferin A, a steroidal lactone isolated from Withania Adpressa , on scopolamine-induced memory impairment in mice

GST activities in mock- and GSTP1 -transfected HepG2 cells were characterized by measuring CDNB conjugation to GSH in total cell lysates ( Table 1 )