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We have recently shown that higher adipogenic capacity of preadipocytes isolated from SAT and VAT from MHO individuals than PO counterparts may be one of the underlying mechanisms for MHO protection due to a greater ability to store TAGs in the SAT depot

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The experiments consider AOD-9604 as a way to influence the early links of the pathological process: to reduce the inflammatory background and create conditions under which tissue degradation proceeds more slowly

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The correlation in our study was increased when T2DM patients concurrently developed CRC, indicating that sRAGE may be depleted with illness and concurrent disease progression and no longer have the capacity to trap additional AGEs