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10.1016/j.taap.2015.10.006 86 SongR.LeiH.FengL.ChengW.LiY.YaoL

Genetic predisposition First-degree relatives have a higher likelihood of developing IC/PBS compared to the general population, indicating that the occurrence of the disease may have a zygotic link, whether monozygotic (identical twins) or dizygotic (fraternal twins) (Warren et al., 2004)

It remains a leading cause of maternal and perinatal morbidity and mortality worldwide

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When mitochondrial function is intact, ATP-sensitive potassium (KATP) channels maintain the stable expression of TrkB, and casein kinase 2 (CK2) participates in the basal phosphorylation of TrkB, ensuring its rapid response to BDNF [109, 110]