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A randomized, double-blind, placebo-controlled trial in 191 older adults (75 years) with moderate vitamin B 12 deficiency (serum cobalamin concentrations of 107-210 pmol/L) without anemia provided participants with 1 mg/day of cyanocobalamin for one year (94)

Lebers hereditary optic neuropathy, a rare genetic disorder affecting the optic nerve, has been associated with rapid optic atrophy following cyanocobalamin administration in some cases

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Clinical trials are ongoing to assess its effectiveness for peripheral nerve damage

This may be related to the bodys increased metabolic activity and detoxification processes

Causes of B12 deficiency include genetic disorders, poor diet, gastrointestinal illness or surgery, alcoholism and use of antacids