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& Holick, M

[22] At the 3-month mark, growth velocity measured from two standing heights taken at least 3 months apart provides the most clinically meaningful early efficacy signal

Swartz RD, Wesley JR, Somermeyer G, Lau K

Receptor activation promotes regulatory T-cell (Treg) differentiation and activity, increases the production of anti-inflammatory cytokines such as interleukin-18 (IL-18), and helps maintain the Th17/Treg balance, thereby attenuating the pro-inflammatory responses characteristic of active IBD [17, 18]

doi: 10.18596/jotcsa.913136 [DOI] [Google Scholar] 33

Efforts to improve pulmonary delivery by reinforcing the mucus barrier have also progressed in the clinic (Table 3)