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This discrepancy was also observed in a previous study by Vogel et al

In regards to its effect on mitochondria, clinical studies have shown that it can stimulate mitochondrial biogenesis, leading to an increase in the number and function of mitochondria within cells (Yue et al., 2022)

However, semaglutide is a single GLP-1 agonist, while retatrutide activates three receptor systems simultaneously, making direct comparisons problematic

It also improves insulin function and reduces cardiovascular risk markers, a systemic metabolic effect beyond simple appetite control