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doi: 10.3945/an.116.013177

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It is an essential cofactor for many enzymes which require thiol-reducing equivalents, and helps to keep redox-sensitive active sites on enzymes in the necessary reduced state

A.10.02, Hewlett-Packard, Waldbronn, Germany)

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Our study is first to demonstrate novel molecular mechanisms involved in the sensitization of PTC cells to ferroptosis inducer- we show that RSL3, a potent direct GPX4 inhibitor, effectively reduces the viability of thyroid cancer lines with various mutational backgrounds compared to HThF control cell line in a dose-dependent manner