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online edn, Oxford Academic, 1 Jan

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These oxidized phosphatidylcholines contribute to ferroptosis by disturbing mitochondrial function and suppressing GPX4 activity, shown in cardiomyocytes during ischemia-reperfusion injury [54]

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In contrast, knock down of Nrf2 suppresses tumor growth, inhibits cell proliferation and promotes increased apoptosis [44, 49]

Its unique biochemical stability, targeted tissue uptake, and capacity to limit oxidative and metal-mediated damage distinguish it from many conventional antioxidants