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Moreover, Cyp2e1-/- mice showed resistance to the APAP high dose-associated hepatotoxicity, whereas human CYP2E1 transgenic mice were susceptible, suggesting that CYP2E1 is the major P450 enzyme participating in APAP activation ( via O-glucuronidation (50%70%) and O-sulfation (approximately 25%) pathways and forms the corresponding conjugates that can be easily excreted by the kidney

Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: a randomized controlled double-blind trial

Identification of genetic risk loci and causal insights associated with parkinson's disease in African and African admixed populations: a genome-wide association study

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-Lipoic acid maintains brain glucose metabolism via BDNF/TrkB/HIF-1 signaling pathway in P301S mice

Both cells were cultured at 37C with 5% CO 2 , generally subcultured every 23 days, and regularly tested for mycoplasma using mycoblue mycoplasma Detector (D101-02, Vazyme)