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57 There may be differences in gene expression induced by gonadal hormones or sex chromosomes in mammals

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Allergic reactions (e.g., ocular swelling, eyelid edema, and conjunctival hyperemia), corneal edema, iritis, ocular inflammation, ocular irritation, superficial keratitis, and superficial ocular infection have been reported in 1% to 10% of patients

Although methylcobalamin and adenosylcobalamin are the bioactive forms of B12, they are unfortunately very chemically unstable outside of the body mainly due to their photosensitivity and therefore more difficult to produce

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This explains the typical presentation of adult males with signs and symptoms of hemochromatosis in the 4 th to 5 th decades, and the slightly later presentation of women, who have additional iron losses due to menstruation, pregnancy, and lactation